This house on the north side of Parque Céspedes is the birthplace of Carlos Manuel de Céspedes, the Father of our Homeland. The house was built at the beginning of the 19th century and it has been a museum since 1968, the centennial anniversary of the signing of the Cuban Declaration of Independence. This museum exhibits pieces of historical value, decorative arts, pieces of furniture and personal objects that belonged to Céspedes, such as his cigar case, the sword, his watch, among others. Also on display is the printing press on which Céspedes published Cuba's first independent newspaper.

La Demajagua Sugar Mill outside Manzanillo is the place where Carlos Manuel de Cespedes freed his slaves and called for rebellion against Spain in 1868. There's a large monument at the entrance to the estate, and you can see the bell used by Céspedes to summon his slaves to freedom. The Museo Histórico La Demajagua, in Céspedes's former home, displays documents, photos, and other artifact related to the Father of our Homeland.

This eclectic museum is housed in the birthplace of composer and violinist Manuel Muñoz Cedeño (1813–95). There are exhibits on the region's colonial history and its geography.