The neighbors of the town insisted to the town council on the need to create a new public square for their amusement. In 1587, the town council decided to use as a public square the area behind the Convento de San Francisco, which was being built at the time. During the latter decades of the 16th century, this square was called the Plaza Nueva (new square), but from the 18th century onwards, once the Plaza del Cristo had been built, it began to become known as the Plaza Vieja (old square). The most remarkable feature of this square are the buildings around it, with their unquestionable historical and artistic importance of having been the blueprint for a style of architecture which, along with certain developments, subsequently spread throughout the city and characterised the Cuban architecture of the 18th century.

The Museo Alejandro de Humboldt (Alejandro de Humboldt Museum) is located in a Colonial house in Plaza de San Francisco de Asís Square, in Old Havana, Cuba. Its name comes from the German scientist Alejandro von Humboldt, who is seen as the second person to discover Cuba. This is a scientific museum dedicated to biology and its main objective is to preserve research and promote the historical Humboldt’s legacy. This institution enhances the labor of Cuban and international personalities whose contributions are considered relevant for the development of culture in general terms. It exhibits the historical trajectory of the scientific and botanic data he compiled throughout the island at the beginning of the 19th century, as well as a botanic exhibition which is fundamentally made up of ferns. In this museum there is a perfect copy of a Kritosaurus skeleton found in the desert and donated by the Mexican government, as well as an enormous Pterosaur skeleton, which is around 10 meters length. The House also has a conference room with capacity for 100 persons and a specialized library on German literature.

A few steps towards Calle Brasil from Plaza del Cristo Square is where the 1886 Museo de la Farmacia Habanera is located. Founded by the Catalonian José Sarrá, it is a shop-museum and nowadays still functions as a pharmacy. The museum displays the history of pharmacies in Havana and their evolution in Cuba. This Pharmacy preserves its original Neo-gothic furniture with Moorish influences, and host a large collection of medicine bottles and medical tools, extracted from archeological excavations in the old city, as well as a book collection with valuable prescriptions for the study of Cuban pharmacopoeia. The museum also exhibits an elegant scale model of an old pharmacy with captivating historical explanations.

The Templete, a small neo-classical style construction, was built in the second half of the 18th Century. It is located in Plaza de Armas. This was the site where the first public mass was celebrated and also the site of the first town council of the nascent town of San Cristóbal de La Habana. The Templete resembles a Doric temple and houses three commemorative canvasses by the famous French painter Juan Bautista Vermey. One of the walls exhibits the plate that declares Old Havana a World Heritage Site.