Camagüey's cathedral is on the southeastern edge of Parque Ignacio Agramonte. The primitive temple was built in 1617, rebuilt at the end of 17 century and beginning of the 18 century. The most recent of several renovations took 15 years and included replacing the wood-beam ceiling. Its refurbished exterior is an attractive beige and yellow. The most impressive aspect of the spacious interior is the large wood-and-marble altar, behind which shine stained glass and a statue of the Virgin Mary. It has a tower with the image of Christ (1937).

The most illustrious son of Camagüey, Ignacio Agramonte (1841-1873), a general killed in battle in the Ten Years’ War, was born here and his birthplace on Plaza de los Trabajadores is now a museum. It is a house from the second half of the 18th century, re-furbished towards 1801. The colonial patio in the house is a typical example of the architectonical design of the colonial period. The museum, inaugurated in 1973, exhibit a collection of documents, testimonials and belongings from the hero that left to history his endless fight for the liberation of Cuba from Spanish rule.

Another splendid feature of Camagüey – and marvelously restored – is Plaza San Juan de Dios, an angular old cobblestoned square surrounded by brightly hued single-storey buildings dating from the 18th century, plus a lovely yellow church with a fine mahogany ceiling and altar, alongside a restored former hospital. It is the most perfect urban assemblage of colonial past colonial and the most singular square of the city. There are several houses of a notable architectural value in the place together with San Juan de Dios Church, a building from 1728.

According to legend, a statue of the Virgin fell from a wagon at this spot in the late 1600s; seeing it as a sign from heaven, the locals built a hermitage for it, which was later replaced by this church, completed in 1776. This church dedicated to Our Lady of Solitude is a beautiful example of Cuban Baroque architecture. Thick, square columns rise into high arches decorated with lovely floral frescoes, above which is a mudejar wooden ceiling with ornate carved beams.