The Museum of Archeology Guamuhaya, founded on May 15th 1976, in a beautiful mansion on the west side of the Plaza Mayor traces pre- and post-Columbian history. It exhibits in chronological order through 8 rooms objects belonging to the aborigines living in the South Central Region of the island of Cuba during the precolumbus era, as well as material evidence of the Colonial period of very diverse origin and a bill from the city of Trinidad and Valle de los Ingenios. Some of these objects are considered unique in Cuba.

A block south of Plaza Mayor stands the grand Palacio Cantero, built in 1830. It has a magnificent ladder and great neoclassical paintings performed by local and Italian artists. Painted pillars, scrolls, shells, pediments and drapes embellish the interior, eclipsing the historical artefacts and old furniture that now form the Trinidad's History Museum. 

Canchánchara is one of the oldest buildings in Trinidad, and combined architectural styles from the 18th and 20th centuries. There's frequently a live band playing in the shady patio, and there are always plenty of soft drinks, cold beer, and such Cuban cocktails as the mojito and the local specialty canchánchara (rum, lime juice, and honey) that will give you the energy to dance and enjoy the Cuban rhythms found in the place.

The Museum of Colonial Architecture on the east side of the main square has examples of woodwork, ironwork, stained glass and other items culled from colonial houses. Museum also offers guided tours through the historic streets of Trinidad.